Malte Bieler Changes in synaptic proteins in hippocampal area CA 1 of a rat learned helpless model of depression
نویسنده
چکیده
Changes in synaptic proteins in hippocampal area CA1 of a rat learned helpless model of depression. (NTNU), but owing to the collaboration of my principle supervisor Professor Ursula Sonnewald (NTNU) I was able to carry out this work in the laboratory of my primary supervisor Professor Svend Davanger (UiO). I thank Professor Ursula Sonnewald for having established this collaboration. I highly appreciate and would like to thank Professor Svend Davanger for the good supervision, the assistance when theoretical issues arose, and his encouragement throughout the project. My thankfulness is likewise directed at PhD student Suleman Hussain who guided me throughout this work and helped me in theoretical and methodological matters. I also would like to thank Karen Marie Gujord for her invaluable help in the training of the experimental methods.
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The effect of ketamine on synaptic transmission and synaptic plasticity in CA1 area of rat hippocampal slices
The effect of ketamine (1-100 µM), which has NMDA receptor antagonist properties, on synaptic transmission and long-term potentiation (LTP) in CAl area of rat hippocampus was examined in vitro. Field potentials were recorded in pyramidal cell layer following Schaffer collateral stimulation. Primed-burst stimulation (PEs) was used for induction of LTP. The amplitude of population spiks (PS) was ...
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